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A comparison of current serum biomarkers as diagnostic indicators of mitochondrial diseases.
- Source :
-
Neurology [Neurology] 2016 May 24; Vol. 86 (21), pp. 2010-5. Date of Electronic Publication: 2016 Apr 27. - Publication Year :
- 2016
-
Abstract
- Objective: To directly compare the diagnostic utility of growth differentiation factor-15 (GDF-15) with our previous fibroblast growth factor-21 (FGF-21) findings in the same adult mitochondrial disease cohort.<br />Methods: Serum GDF-15 levels were measured using a quantitative ELISA. Statistical analyses of GDF-15 data were compared with our published FGF-21 findings.<br />Results: Median serum GDF-15 concentrations were elevated in patients with mitochondrial disease and differed between all experimental groups, mirroring group results for FGF-21. There was a difference between patients diagnosed by muscle biopsy and genetic diagnosis, suggesting that serum GDF-15 measurement may be more broadly specific for mitochondrial disease than for muscle manifesting mitochondrial disease, in contrast to FGF-21. GDF-15 showed a markedly higher diagnostic odds ratio when compared with FGF-21 (75.3 vs 45.7), was a better predictor of disease based on diagnostic sensitivity (77.8% vs 68.5%), and outperformed FGF-21 on receiver operating characteristic curve analysis (area under the curve 94.1% vs 91.1%). Combining both biomarkers did not improve the area under the curve remarkably over GDF-15 alone. GDF-15 was the best predictor of mitochondrial disease (p < 0.002) following multivariate logistic regression analysis.<br />Conclusions: GDF-15 outperforms FGF-21 as an indicator of mitochondrial diseases. Our data suggest that GDF-15 is generally indicative of inherited mitochondrial disease regardless of clinical phenotype, whereas FGF-21 seems to be more indicative of mitochondrial disease when muscle manifestations are present.<br />Classification of Evidence: This study provides Class III evidence that serum GDF-15 accurately distinguishes patients with mitochondrial diseases from those without them.<br /> (© 2016 American Academy of Neurology.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Area Under Curve
Biomarkers blood
Biopsy
Blood Chemical Analysis
Cohort Studies
Enzyme-Linked Immunosorbent Assay
Female
Humans
Logistic Models
Male
Middle Aged
Mitochondrial Diseases genetics
Mitochondrial Diseases pathology
Multivariate Analysis
Muscles pathology
Odds Ratio
ROC Curve
Young Adult
Fibroblast Growth Factors blood
Growth Differentiation Factor 15 blood
Mitochondrial Diseases blood
Subjects
Details
- Language :
- English
- ISSN :
- 1526-632X
- Volume :
- 86
- Issue :
- 21
- Database :
- MEDLINE
- Journal :
- Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 27164684
- Full Text :
- https://doi.org/10.1212/WNL.0000000000002705