A combination of soy isoflavones and cello-oligosaccharides changes equol/O-desmethylangolensin production ratio and attenuates bone fragility in ovariectomized mice.

Authors :: Fujii S
Takahashi N
Inoue H
Katsumata S
Kikkawa Y
Machida M
Ishimi Y
Uehara M
Source :: Bioscience, biotechnology, and biochemistry [Biosci Biotechnol Biochem] 2016 Aug; Vol. 80 (8), pp. 1632-5. Date of Electronic Publication: 2016 May 18.
Publication Year :: 2016
Abstract: We examined the cooperative effects of isoflavones and cello-oligosaccharides on daidzein metabolism and bone fragility in ovariectomized mice. Cello-oligosaccharides increased urinary equol and decreased O-desmethylangolensin. A combination of isoflavones and cello-oligosaccharides attenuated decreases in bone breaking force and stiffness caused by ovariectomy. Combination treatment with isofalvones and cello-oligosaccharides increases urinary equol/O-desmethylangolensin production ratio and prevents ovariectomy-induced abnormalities in bone strength.

Subjects :: Absorptiometry, Photon
Animals
Bone Density drug effects
Female
Femur drug effects
Femur metabolism
Femur pathology
Food, Formulated
Fractures, Bone metabolism
Fractures, Bone pathology
Genistein urine
Isoflavones urine
Mice
Glycine max chemistry
Cellobiose administration & dosage
Equol urine
Fractures, Bone prevention & control
Isoflavones administration & dosage
Ovariectomy

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