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Apolipoproteins L control cell death triggered by TLR3/TRIF signaling in dendritic cells.
- Source :
-
European journal of immunology [Eur J Immunol] 2016 Aug; Vol. 46 (8), pp. 1854-66. Date of Electronic Publication: 2016 Jun 08. - Publication Year :
- 2016
-
Abstract
- Apolipoproteins L (ApoLs) are Bcl-2-like proteins expressed under inflammatory conditions in myeloid and endothelial cells. We found that Toll-like receptor (TLR) stimuli, particularly the viral mimetic polyinosinic:polycytidylic acid (poly(I:C)), specifically induce ApoLs7/11 subfamilies in murine CD8α(+)  dendritic cells (DCs). This induction requires the TLR3/TRIF (where TRIF is TIR domain containing adapter-inducing interferon β) signaling pathway and is dependent on IFN-β in all ApoLs subfamilies except for ApoL7c. Poly(I:C) treatment of DCs is also associated with induction of both cell death and autophagy. ApoLs expression is related to promotion of DC death by poly(I:C), as ApoLs7/11 knockdown increases DC survival and ApoLs7 are associated with the anti-apoptotic protein Bcl-xL (where Bcl-xL is B-cell lymphoma extra large). Similarly, in human monocyte-derived DCs poly(I:C) induces both cell death and the expression of ApoLs, principally ApoL3. Finally, the BH3-like peptide of ApoLs appears to be involved in the DC death-promoting activity. We would like to propose that ApoLs are involved in cell death linked to activation of DCs by viral stimuli.<br /> (© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Adaptor Proteins, Vesicular Transport genetics
Adaptor Proteins, Vesicular Transport metabolism
Animals
CD8 Antigens metabolism
Cell Line
Cells, Cultured
Dendritic Cells metabolism
Humans
Interferon-beta pharmacology
Mice
Mice, Inbred C57BL
Mice, Knockout
Poly I-C pharmacology
Protein Isoforms immunology
bcl-X Protein metabolism
Apolipoproteins immunology
Apoptosis
Dendritic Cells cytology
Signal Transduction
Toll-Like Receptor 3 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1521-4141
- Volume :
- 46
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- European journal of immunology
- Publication Type :
- Academic Journal
- Accession number :
- 27198486
- Full Text :
- https://doi.org/10.1002/eji.201546252