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Synthesis of the dodecapeptide corresponding to domain III of bovine brain calmodulin: alpha-beta shift side reactions during the synthesis by the classical method in solution.
- Source :
-
Biopolymers [Biopolymers] 1989 Jan; Vol. 28 (1), pp. 333-52. - Publication Year :
- 1989
-
Abstract
- We report details of the chemical synthesis of the dodecapeptide corresponding to the calcium binding loop III of bovine brain calmodulin (sequence 93-104) and its fragments 96-04, 93-98, and 99-104. The preparation of the peptides employed classical solution methods and a fragment-condensation strategy. The major difficulties were encountered during the synthesis of the peptides containing the N-terminal sequences -Gly-Asn-Gly- and -Asp-Lys-Asp-Gly-Ans-Gly-, in which alpha-beta shift side reactions were observed.
Details
- Language :
- English
- ISSN :
- 0006-3525
- Volume :
- 28
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Biopolymers
- Publication Type :
- Academic Journal
- Accession number :
- 2720112
- Full Text :
- https://doi.org/10.1002/bip.360280133