Complete Nucleotide Sequence of an IncI2 Plasmid Coharboring blaCTX-M-55 and mcr-1.

Authors :: Sun J
Li XP
Yang RS
Fang LX
Huo W
Li SM
Jiang P
Liao XP
Liu YH
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2016 Jul 22; Vol. 60 (8), pp. 5014-7. Date of Electronic Publication: 2016 Jul 22 (Print Publication: 2016).
Publication Year :: 2016
Abstract: We report the complete nucleotide sequence of a plasmid, pA31-12, carrying blaCTX-M-55 and mcr-1 from a chicken Escherichia coli isolate. pA31-12 has an IncI2 replicon that displays extensive sequence similarity with pHN1122-1-borne blaCTX-M-55 and pHNSHP45-borne mcr-1 Insertion sequences ISEcp1 and ISApl1 are responsible for the mobilization of blaCTX-M-55 and mcr-1, respectively. The colocalization of mcr-1 with an extended-spectrum β-lactamase gene on a conjugative plasmid may accelerate the dissemination of both genes by coselection.<br /> (Copyright © 2016, American Society for Microbiology. All Rights Reserved.)

Subjects :: Base Sequence genetics
Escherichia coli genetics
Escherichia coli Proteins genetics
Plasmids genetics
beta-Lactamases genetics

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