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Novel gene and cellular therapy approaches for treating HIV.
- Source :
-
Discovery medicine [Discov Med] 2016 Apr; Vol. 21 (116), pp. 283-92. - Publication Year :
- 2016
-
Abstract
- Advances in HIV drug therapy have drastically decreased mortality and significantly improved quality of life for HIV infected patients since the early days of the epidemic. However, HIV drug-resistance, drug toxicities, therapy adherence, and the need for life-long treatment remain major challenges that continue to contribute to HIV-related global health concerns. Recent advances in cancer immunotherapy have proven the potency of cellular gene therapies. An ever-growing toolbox of methods of gene manipulation, cell modification, and clinical cell manufacturing, will enable moving beyond continuous drug therapy for more effective and durable treatments, including the possibility of inducing permanent resistance to HIV. These approaches, which target both host and viral factors, capitalize on points of vulnerability in the virus life cycle. Cellular and gene therapy has the potential to be an effective one-time therapy with less toxicity. Here, we review several promising strategies currently in pre-clinical development and clinical trials.
- Subjects :
- Anti-Retroviral Agents adverse effects
Anti-Retroviral Agents therapeutic use
CRISPR-Cas Systems genetics
Cell- and Tissue-Based Therapy adverse effects
DNA-Binding Proteins genetics
Drug Resistance, Viral
Endoribonucleases genetics
Escherichia coli Proteins genetics
Gene Transfer Techniques
Genetic Therapy adverse effects
HIV Infections immunology
HIV-1 drug effects
Humans
Quality of Life
Receptors, CCR5 genetics
Transcription Activator-Like Effector Nucleases genetics
Transplantation, Autologous methods
rev Gene Products, Human Immunodeficiency Virus genetics
Cell- and Tissue-Based Therapy methods
Genetic Therapy methods
HIV Infections therapy
HIV-1 physiology
T-Lymphocytes transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 1944-7930
- Volume :
- 21
- Issue :
- 116
- Database :
- MEDLINE
- Journal :
- Discovery medicine
- Publication Type :
- Academic Journal
- Accession number :
- 27232514