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Heterogeneous Pathology of Melasma and Its Clinical Implications.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2016 May 26; Vol. 17 (6). Date of Electronic Publication: 2016 May 26. - Publication Year :
- 2016
-
Abstract
- Melasma is a commonly acquired hypermelanosis that affects sun-exposed areas of the skin, with frequent facial involvement. Its histologic manifestations are evident in the epidermis, extracellular matrix, and dermis. In addition to epidermal pigmentation, pathologic findings of melasma include extracellular matrix abnormality, especially solar elastosis. The disrupted basement membrane has been described in melasma with variable incidences. In the dermis, an increase in vascularity and an increase in the number of mast cells were observed, indicating that dermal factors have critical roles in the pathogenesis of melasma, despite the fact that melasma is characterized by epidermal hyperpigmentation. This review discusses such histologic characteristics of melasma, with consideration to their implications for melasma treatment.
- Subjects :
- Administration, Topical
Antioxidants administration & dosage
Antioxidants therapeutic use
Basement Membrane metabolism
Basement Membrane pathology
Chloroquine administration & dosage
Chloroquine therapeutic use
Dermis metabolism
Dermis pathology
Disease Management
Gene Expression Regulation
Humans
Hydroquinones administration & dosage
Laser Therapy
Mast Cells metabolism
Mast Cells pathology
Melanosis metabolism
Phototherapy
Melanosis pathology
Melanosis therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 17
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 27240341
- Full Text :
- https://doi.org/10.3390/ijms17060824