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Interim Guidance for Interpretation of Zika Virus Antibody Test Results.
- Source :
-
MMWR. Morbidity and mortality weekly report [MMWR Morb Mortal Wkly Rep] 2016 Jun 03; Vol. 65 (21), pp. 543-6. Date of Electronic Publication: 2016 Jun 03. - Publication Year :
- 2016
-
Abstract
- Zika virus is a single-stranded RNA virus in the genus Flavivirus and is closely related to dengue, West Nile, Japanese encephalitis, and yellow fever viruses (1,2). Among flaviviruses, Zika and dengue virus share similar symptoms of infection, transmission cycles, and geographic distribution. Diagnostic testing for Zika virus infection can be accomplished using both molecular and serologic methods. For persons with suspected Zika virus disease, a positive real-time reverse transcription-polymerase chain reaction (rRT-PCR) result confirms Zika virus infection, but a negative rRT-PCR result does not exclude infection (3-7). In these cases, immunoglobulin (Ig) M and neutralizing antibody testing can identify additional recent Zika virus infections (6,7). However, Zika virus antibody test results can be difficult to interpret because of cross-reactivity with other flaviviruses, which can preclude identification of the specific infecting virus, especially when the person previously was infected with or vaccinated against a related flavivirus (8). This is important because the results of Zika and dengue virus testing will guide clinical management. Pregnant women with laboratory evidence of Zika virus infection should be evaluated and managed for possible adverse pregnancy outcomes and be reported to the U.S. Zika Pregnancy Registry or the Puerto Rico Zika Active Pregnancy Surveillance System for clinical follow-up (9,10). All patients with clinically suspected dengue should have proper management to reduce the risk for hemorrhage and shock (11). If serologic testing indicates recent flavivirus infection that could be caused by either Zika or dengue virus, patients should be clinically managed for both infections because they might have been infected with either virus.
- Subjects :
- Centers for Disease Control and Prevention, U.S.
Dengue diagnosis
Dengue therapy
Female
Humans
Pregnancy
United States
Zika Virus Infection therapy
Antibodies, Viral isolation & purification
Diagnostic Tests, Routine
Practice Guidelines as Topic
Zika Virus immunology
Zika Virus Infection diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1545-861X
- Volume :
- 65
- Issue :
- 21
- Database :
- MEDLINE
- Journal :
- MMWR. Morbidity and mortality weekly report
- Publication Type :
- Academic Journal
- Accession number :
- 27254248
- Full Text :
- https://doi.org/10.15585/mmwr.mm6521e1