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Good responders to catheter ablation for long-standing persistent atrial fibrillation: Clinical and genetic characteristics.
- Source :
-
Journal of cardiology [J Cardiol] 2017 Mar; Vol. 69 (3), pp. 584-590. Date of Electronic Publication: 2016 May 31. - Publication Year :
- 2017
-
Abstract
- Background: Radiofrequency catheter ablation (RFCA) for long-standing persistent atrial fibrillation (L-PeAF) is challenging and has a relatively high recurrence rate. We explored clinical and genetic characteristics associated with being good responders (no early or clinical recurrence within 12 months in the absence of anti-arrhythmic drugs) to RFCA among patients with L-PeAF.<br />Methods: Of 1319 patients in the Yonsei AF Ablation Cohort, this study included 141 consecutive patients with L-PeAF (80.9% male, age 57.8±9.7 years) who were followed >12 months after RFCA.<br />Results: During 25 (19-35) months follow-up, the recurrence rate was 39%, and 38 patients (27%) were categorized as good responders, those had a shorter AF duration (p=0.010), and smaller left atrial (LA) size (p=0.033) than others. The rs2106216 (16q22/ZFHX3) genetic polymorphism was independently associated with being a good responder in multivariate analysis (adjusted OR=2.70, 95% CI 1.41-5.14, p=0.003), after adjusting for LA size and AF duration. The rs2106261 had predictive value for clinical recurrence of AF after RFCA among patients with an AF duration 12-65 months (log rank, p=0.025).<br />Conclusions: Despite a relatively high recurrence rate after RFCA for L-PeAF, patients with a shorter AF duration and smaller LA size showed a more favorable outcome. The rs2106216 polymorphism (ZFHX3) was independently associated with being good responders to RFCA for L-PeAF, especially with AF duration 12-65 months.<br /> (Copyright © 2016 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Atrial Fibrillation pathology
Female
Genotype
Heart Atria pathology
Humans
Male
Middle Aged
Multivariate Analysis
Polymorphism, Single Nucleotide
Postoperative Complications
Recurrence
Time Factors
Treatment Outcome
Atrial Fibrillation genetics
Atrial Fibrillation surgery
Catheter Ablation adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1876-4738
- Volume :
- 69
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 27261248
- Full Text :
- https://doi.org/10.1016/j.jjcc.2016.04.017