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Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2014-2015.
- Source :
-
Antiviral research [Antiviral Res] 2016 Aug; Vol. 132, pp. 178-85. Date of Electronic Publication: 2016 Jun 03. - Publication Year :
- 2016
-
Abstract
- The World Health Organization (WHO) Collaborating Centres for Reference and Research on Influenza (WHO CCs) tested 13,312 viruses collected by WHO recognized National Influenza Centres between May 2014 and May 2015 to determine 50% inhibitory concentration (IC50) data for neuraminidase inhibitors (NAIs) oseltamivir, zanamivir, peramivir and laninamivir. Ninety-four per cent of the viruses tested by the WHO CCs were from three WHO regions: Western Pacific, the Americas and Europe. Approximately 0.5% (n = 68) of viruses showed either highly reduced inhibition (HRI) or reduced inhibition (RI) (n = 56) against at least one of the four NAIs. Of the twelve viruses with HRI, six were A(H1N1)pdm09 viruses, three were A(H3N2) viruses and three were B/Yamagata-lineage viruses. The overall frequency of viruses with RI or HRI by the NAIs was lower than that observed in 2013-14 (1.9%), but similar to the 2012-13 period (0.6%). Based on the current analysis, the NAIs remain an appropriate choice for the treatment and prophylaxis of influenza virus infections.<br /> (Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Antiviral Agents therapeutic use
Databases, Factual
Dose-Response Relationship, Drug
Drug Resistance, Viral
Global Health
History, 21st Century
Humans
Influenza A virus classification
Influenza A virus genetics
Influenza, Human drug therapy
Influenza, Human history
Microbial Sensitivity Tests
Mutation
Neuraminidase genetics
Population Surveillance
Viral Proteins genetics
World Health Organization
Antiviral Agents pharmacology
Influenza A virus drug effects
Influenza A virus enzymology
Influenza, Human epidemiology
Influenza, Human virology
Neuraminidase antagonists & inhibitors
Viral Proteins antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1872-9096
- Volume :
- 132
- Database :
- MEDLINE
- Journal :
- Antiviral research
- Publication Type :
- Academic Journal
- Accession number :
- 27265623
- Full Text :
- https://doi.org/10.1016/j.antiviral.2016.06.001