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Real-world treatment patterns and associated progression-free survival in relapsed/refractory multiple myeloma among US community oncology practices.
- Source :
-
Expert review of hematology [Expert Rev Hematol] 2016 Jul; Vol. 9 (7), pp. 707-17. Date of Electronic Publication: 2016 Jun 16. - Publication Year :
- 2016
-
Abstract
- Background: Evidence supporting optimal treatment sequencing in relapsed/refractory multiple myeloma (RRMM) patients requiring multiple therapy lines is lacking.<br />Methods: Using retrospective chart data, this study describes real-world RRMM treatment patterns and related progression-free survival (PFS) in US community oncology clinics.<br />Results: Bortezomib ± a non-immunomodulatory drug (IMiD), lenalidomide ± a non-proteasome inhibitor (PI), bortezomib + an IMiD were the most commonly used regimens in early lines of therapy. Median PFS was similar in 1(st) (11.1 months) and 2(nd) line (10.5) and decreased in lines 3 through 5 (3(rd): 7.9; 4(th): 7.2, 5(th): 5.4). Longest PFS (12.5 months) in first line was with bortezomib + ImiD; longest PFS in second line was with lenalidomide ± a non-PI was (13.2 months).<br />Conclusions: Re-treatment with bortezomib was common; novel agents were reserved for later therapy lines. Overall, the observed PFS associated with real-world treatment sequences were shorter than those reported in clinical trials.
- Subjects :
- Aged
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Disease-Free Survival
Drug Resistance, Neoplasm
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Multiple Myeloma diagnosis
Multiple Myeloma epidemiology
Neoplasm Staging
Population Surveillance
Recurrence
Retrospective Studies
United States epidemiology
Multiple Myeloma mortality
Multiple Myeloma therapy
Practice Patterns, Physicians'
Subjects
Details
- Language :
- English
- ISSN :
- 1747-4094
- Volume :
- 9
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Expert review of hematology
- Publication Type :
- Academic Journal
- Accession number :
- 27291638
- Full Text :
- https://doi.org/10.1080/17474086.2016.1195254