Back to Search Start Over

[Changes in the CD8+ Density of Tumor Infiltrating Lymphocytes after Neoadjuvant Radiochemotherapy in Patients with Rectal Adenocarcinom].

[Changes in the CD8+ Density of Tumor Infiltrating Lymphocytes after Neoadjuvant Radiochemotherapy in Patients with Rectal Adenocarcinom].

Authors :
Buka D
Dvořák J
Sitorová V
Hátlová J
Richter I
Sirák I
Source :
Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti [Klin Onkol] 2016; Vol. 29 (3), pp. 204-9.
Publication Year :
2016

Abstract

Background: The goal of this study is to examine the effect of neoadjuvant radiochemotherapy on the density of CD8(+) tumor infiltrating lymphocytes (TILs) in endoscopical biopsies and resection specimens from patients with rectal adenocarcinoma before and after therapy.<br />Patients and Methods: In total, 53 patients with locally advanced rectal cancer were studied.<br />Results: The median density of CD8(+) TILs in pretreatment biopsies was 12 (1- 232) and that in surgical specimens after radiochemotherapy was 18 (1- 319). During radiochemotherapy, the density of CD8(+) TILs increased in 30 patients (57%), decreased in 18 (34%), and did not change in one. It was not possible to assess the dynamics of CD8(+) TILs density in four patients. The increased density of CD8(+) TILs after radiochemotherapy was associated with a median survival rate 2.5 times longer than that associated with no increase in density.<br />Conclusion: In the present study, the density of CD8(+) TILs in endoscopical biopsies before radiochemotherapy, the density in resection specimens after radiochemotherapy, or in changes in the density after radiochemotherapy showed no predictive or prognostic significance. However, studying a larger number of patients may show that CD8(+) TILs density is of predictive or prognostic significance.

Details

Language :
Czech
ISSN :
0862-495X
Volume :
29
Issue :
3
Database :
MEDLINE
Journal :
Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti
Publication Type :
Academic Journal
Accession number :
27296405
Full Text :
https://doi.org/10.14735/amko2016204