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[Changes in the CD8+ Density of Tumor Infiltrating Lymphocytes after Neoadjuvant Radiochemotherapy in Patients with Rectal Adenocarcinom].
[Changes in the CD8+ Density of Tumor Infiltrating Lymphocytes after Neoadjuvant Radiochemotherapy in Patients with Rectal Adenocarcinom].
- Source :
-
Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti [Klin Onkol] 2016; Vol. 29 (3), pp. 204-9. - Publication Year :
- 2016
-
Abstract
- Background: The goal of this study is to examine the effect of neoadjuvant radiochemotherapy on the density of CD8(+) tumor infiltrating lymphocytes (TILs) in endoscopical biopsies and resection specimens from patients with rectal adenocarcinoma before and after therapy.<br />Patients and Methods: In total, 53 patients with locally advanced rectal cancer were studied.<br />Results: The median density of CD8(+) TILs in pretreatment biopsies was 12 (1- 232) and that in surgical specimens after radiochemotherapy was 18 (1- 319). During radiochemotherapy, the density of CD8(+) TILs increased in 30 patients (57%), decreased in 18 (34%), and did not change in one. It was not possible to assess the dynamics of CD8(+) TILs density in four patients. The increased density of CD8(+) TILs after radiochemotherapy was associated with a median survival rate 2.5 times longer than that associated with no increase in density.<br />Conclusion: In the present study, the density of CD8(+) TILs in endoscopical biopsies before radiochemotherapy, the density in resection specimens after radiochemotherapy, or in changes in the density after radiochemotherapy showed no predictive or prognostic significance. However, studying a larger number of patients may show that CD8(+) TILs density is of predictive or prognostic significance.
Details
- Language :
- Czech
- ISSN :
- 0862-495X
- Volume :
- 29
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti
- Publication Type :
- Academic Journal
- Accession number :
- 27296405
- Full Text :
- https://doi.org/10.14735/amko2016204