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Low-dose oral cholecalciferol is associated with higher numbers of Helios(+) and total Tregs than oral calcitriol in renal allograft recipients: an observational study.
- Source :
-
BMC pharmacology & toxicology [BMC Pharmacol Toxicol] 2016 Jun 14; Vol. 17 (1), pp. 24. Date of Electronic Publication: 2016 Jun 14. - Publication Year :
- 2016
-
Abstract
- Background: Regulatory T cells (Tregs) are a cornerstone of graft acceptance. High numbers of Tregs are associated with better long-term graft survival. Recently, Vitamin D was suggested as an immunomodulator, in addition to its classical role in calcium metabolism. Vitamin D modulates Tregs and might, thereby, promote graft acceptance and long-term graft survival.<br />Methods: One hundred twenty-three renal allograft recipients attending either Heidelberg nephrology or Giessen internal medicine clinic were enrolled in this cross- sectional study. Sixteen healthy controls were studied in addition. Sixty-nine patients were receiving no vitamin D, 38 calcitriol, and 16 cholecalciferol supplementations. We evaluated whether there was a difference in the absolute numbers of Helios(+), Helios(-), CTLA-4(+), IFNg(+), and total Tregs among the patient groups.<br />Results: Cholecalciferol supplementation was associated with higher absolute numbers of Helios(+), CTLA-4(+), and total Tregs than calcitriol (p < 0.001, p = 0.004, p = 0.001 respectively). Helios(+) Tregs were also higher in cholecalciferol than no vitamin D supplementation patients (p = 0.001), whereas CTLA-4(+) and total Tregs were similar in both groups (p = NS). Helios(+), Helios(-), CTLA-4(+), IFNg(+), and total Tregs were similar in the cholecalciferol and healthy control groups (p = NS).<br />Conclusion: Our findings indicate that cholecalciferol, even when administered at low dosages, has a stabilizing effect on Tregs (particularly the Helios + subset), in contrast to calcitriol which showed neither a stabilizing nor a proliferation-inducing effect on the same cell population.
- Subjects :
- Administration, Oral
Adult
Aged
Allografts drug effects
Allografts metabolism
Cross-Sectional Studies
Female
Graft Survival drug effects
Humans
Kidney Transplantation trends
Male
Middle Aged
T-Lymphocytes, Regulatory drug effects
Calcitriol administration & dosage
Cholecalciferol administration & dosage
Graft Survival physiology
Ikaros Transcription Factor blood
Kidney Transplantation adverse effects
T-Lymphocytes, Regulatory metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2050-6511
- Volume :
- 17
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC pharmacology & toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 27296673
- Full Text :
- https://doi.org/10.1186/s40360-016-0066-9