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Baseline retrobulbar blood flow is associated with both functional and structural glaucomatous progression after 4 years.
- Source :
-
The British journal of ophthalmology [Br J Ophthalmol] 2017 Mar; Vol. 101 (3), pp. 305-308. Date of Electronic Publication: 2016 Jun 13. - Publication Year :
- 2017
-
Abstract
- Background/aims: Previous studies suggest that vascular abnormalities are involved in the pathogenesis of open-angle glaucoma. This study aims to examine the relationship of baseline retrobulbar blood flow measurements with functional and structural glaucomatous progression in patients with open-angle glaucoma over 4 years.<br />Methods: In this study, 112 patients with open-angle glaucoma were examined at baseline and 78 with retrobulbar blood flow assessments were followed to 4 years. Colour Doppler imaging was used to evaluate retrobulbar blood flow. Structural disease progression was examined with optical coherence tomography and Heidelberg Retinal Tomography III. Functional disease progression was monitored with automated perimetry using Humphrey visual fields. Mixed-model analysis of covariance was used to test for significance of changes from baseline to 4-year follow-up. Two-sample t tests and χ <superscript>2</superscript> tests were used to test for baseline blood flow differences between patients who progressed and those who did not progress.<br />Results: Patients who progressed structurally had a statistically significant lower baseline mean ophthalmic artery peak systolic velocity (PSV) (p=0.024) and ophthalmic artery end diastolic velocity (EDV) (p=0.012) compared with those who did not progress. Similarly, a lower baseline mean ophthalmic artery PSV (p=0.031) and ophthalmic artery EDV (p=0.005) were associated with patients who progressed functionally compared with those who did not progress after 4 years.<br />Conclusions: In this study population, lower baseline ophthalmic artery blood flow velocities were associated with simultaneous structural and functional glaucoma progression after 4 years.<br />Competing Interests: Competing interests: AH would like to disclose that he receives remuneration from Stemnion, Biolight, Nano Retina, AdOM, Science Based Health, Isarna Therapeutics, and Ono Pharmaceuticals for serving as a consultant. He also holds an ownership interest in AdOM, Nano Retina and Oxymap. All relationships listed above are pursuant to Indiana University's policy on outside activities.<br /> (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.)
- Subjects :
- Aged
Blood Flow Velocity physiology
Disease Progression
Female
Follow-Up Studies
Humans
Intraocular Pressure physiology
Laser-Doppler Flowmetry
Male
Middle Aged
Nerve Fibers pathology
Regional Blood Flow physiology
Retinal Ganglion Cells pathology
Tomography, Optical Coherence
Visual Field Tests
Visual Fields physiology
Ciliary Arteries physiology
Glaucoma, Open-Angle diagnosis
Glaucoma, Open-Angle physiopathology
Ophthalmic Artery physiology
Retinal Artery physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1468-2079
- Volume :
- 101
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The British journal of ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 27297218
- Full Text :
- https://doi.org/10.1136/bjophthalmol-2016-308460