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Toward Community Standards and Software for Whole-Cell Modeling.
- Source :
-
IEEE transactions on bio-medical engineering [IEEE Trans Biomed Eng] 2016 Oct; Vol. 63 (10), pp. 2007-14. Date of Electronic Publication: 2016 Jun 10. - Publication Year :
- 2016
-
Abstract
- Objective: Whole-cell (WC) modeling is a promising tool for biological research, bioengineering, and medicine. However, substantial work remains to create accurate comprehensive models of complex cells.<br />Methods: We organized the 2015 Whole-Cell Modeling Summer School to teach WC modeling and evaluate the need for new WC modeling standards and software by recoding a recently published WC model in the Systems Biology Markup Language.<br />Results: Our analysis revealed several challenges to representing WC models using the current standards.<br />Conclusion: We, therefore, propose several new WC modeling standards, software, and databases.<br />Significance: We anticipate that these new standards and software will enable more comprehensive models.
Details
- Language :
- English
- ISSN :
- 1558-2531
- Volume :
- 63
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- IEEE transactions on bio-medical engineering
- Publication Type :
- Academic Journal
- Accession number :
- 27305665
- Full Text :
- https://doi.org/10.1109/TBME.2016.2560762