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GD2 and GD3 synthase: novel drug targets for cancer therapy.
- Source :
-
Molecular & cellular oncology [Mol Cell Oncol] 2015 Mar 09; Vol. 2 (3), pp. e975068. Date of Electronic Publication: 2015 Mar 09 (Print Publication: 2015). - Publication Year :
- 2015
-
Abstract
- Our recent study suggests that targeting GD3 synthase (also known as ST8SIA1)-the rate-limiting enzyme in biosynthesis of the breast cancer stem cell marker GD2-abrogates metastasis and depletes the cancer stem cell populations within a tumor, thus providing an effective therapeutic strategy against metastatic breast cancers.
Details
- Language :
- English
- ISSN :
- 2372-3556
- Volume :
- 2
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Molecular & cellular oncology
- Publication Type :
- Academic Journal
- Accession number :
- 27308452
- Full Text :
- https://doi.org/10.4161/23723556.2014.975068