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Impact of combination therapy 5-alpha reductase inhibitors (5-ARI) plus alpha-blockers (AB) on erectile dysfunction and decrease of libido in patients with LUTS/BPH: a systematic review with meta-analysis.
- Source :
-
The aging male : the official journal of the International Society for the Study of the Aging Male [Aging Male] 2016 Sep; Vol. 19 (3), pp. 175-181. Date of Electronic Publication: 2016 Jun 16. - Publication Year :
- 2016
-
Abstract
- Lower urinary tract symptoms (LUTS) secondary to benign prostatic obstruction (BPO) represent one of the most common clinical complaints in adult men. Several drugs used for LUTS/BPO may strongly affect sexual function and bother. The aim of this systematic review and meta-analysis was to evaluate the impact of combination therapy with alpha-blockers (AB), 5-alpha reductase inhibitors (5-ARI) on the risk of erectile dysfunction(ED) and libido alterations (LA) from randomized clinical trial (RCT). Based on the inclusion and exclusion criteria, five RCTs involving 6131 patients were included in the analysis. According to the analysis, the overall prevalence of ED and LA were significantly greater in the combination treatment group than in the AB group (7.93% versus 4.66%; OR 1.81; p < 0.0001 and 3.69% versus 2.36%; OR 1.58; p = 0.003, respectively). The combination therapy increased the risk of ED compared to monotherapy with 5-ARI (7.93% versus 6.47%; OR 1.25; p = 0.04) but not the risk of LA (3.51% versus 3.37; OR 1.03; p = 0.84). In our systematic meta-analysis, we demonstrated that combination therapy with ABs and 5-ARIs was associated with significantly higher risk of ED and LA compared with single monotherapy. Combination therapy showed similar risk of LA compared with 5-ARI monotherapy.
- Subjects :
- 5-alpha Reductase Inhibitors administration & dosage
Adrenergic alpha-Antagonists administration & dosage
Drug Therapy, Combination
Erectile Dysfunction etiology
Humans
Lower Urinary Tract Symptoms drug therapy
Male
Prostatic Hyperplasia drug therapy
5-alpha Reductase Inhibitors therapeutic use
Adrenergic alpha-Antagonists therapeutic use
Erectile Dysfunction drug therapy
Libido drug effects
Lower Urinary Tract Symptoms complications
Prostatic Hyperplasia complications
Subjects
Details
- Language :
- English
- ISSN :
- 1473-0790
- Volume :
- 19
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The aging male : the official journal of the International Society for the Study of the Aging Male
- Publication Type :
- Academic Journal
- Accession number :
- 27310433
- Full Text :
- https://doi.org/10.1080/13685538.2016.1195361