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The use of enhanced half-life coagulation factor concentrates in routine clinical practice: guidance from UKHCDO.
- Source :
-
Haemophilia : the official journal of the World Federation of Hemophilia [Haemophilia] 2016 Jul; Vol. 22 (4), pp. 487-98. Date of Electronic Publication: 2016 Jun 16. - Publication Year :
- 2016
-
Abstract
- Enhanced half-life factor VIII and IX products are being introduced into routine clinical practice. Published data report on clinical trials and there are limited data available on how to use these products in routine clinical practice. Many patients, for example, those with a past history of an inhibitor, have been excluded from clinical trials and there are limited data published on children. This guidance document is a consensus statement from the UK Haemophilia Centres Doctors' Organisation and aims to give pragmatic advice on the use of these products in routine practice.<br /> (© 2016 John Wiley & Sons Ltd.)
- Subjects :
- Antibodies, Neutralizing blood
Coagulants chemistry
Coagulants pharmacokinetics
Factor IX chemistry
Factor IX pharmacokinetics
Factor VIII chemistry
Factor VIII pharmacokinetics
Half-Life
Hemorrhage prevention & control
Humans
Polyethylene Glycols chemistry
Recombinant Fusion Proteins biosynthesis
Recombinant Fusion Proteins pharmacokinetics
Recombinant Fusion Proteins therapeutic use
Coagulants therapeutic use
Factor IX therapeutic use
Factor VIII therapeutic use
Hemophilia A drug therapy
Hemophilia B drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2516
- Volume :
- 22
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Haemophilia : the official journal of the World Federation of Hemophilia
- Publication Type :
- Academic Journal
- Accession number :
- 27311929
- Full Text :
- https://doi.org/10.1111/hae.13013