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Does ibuprofen treatment in patent ductus arteriosus alter oxygen free radicals in premature infants?
- Source :
-
Cardiology in the young [Cardiol Young] 2017 Apr; Vol. 27 (3), pp. 507-511. Date of Electronic Publication: 2016 Jun 20. - Publication Year :
- 2017
-
Abstract
- Introduction Ibuprofen is used widely to close patent ductus arteriosus in preterm infants. The anti-inflammatory activity of ibuprofen may also be partly due to its ability to scavenge reactive oxygen species and reactive nitrogen species. We evaluated the interaction between oxidative status and the medical treatment of patent ductus arteriosus with two forms of ibuprofen. Materials and methods This study enrolled newborns of gestational age ⩽32 weeks, birth weight ⩽1500 g, and postnatal age 48-96 hours, who received either intravenous or oral ibuprofen to treat patent ductus arteriosus. Venous blood was sampled before ibuprofen treatment from each patient to determine antioxidant and oxidant concentrations. Secondary samples were collected 24 hours after the end of the treatment. Total oxidant status and total antioxidant capacity were measured using Erel's method.<br />Results: This prospective randomised study enrolled 102 preterm infants with patent ductus arteriosus. The patent ductus arteriosus closure rate was significantly higher in the oral ibuprofen group (84.6 versus 62%) after the first course of treatment (p=0.011). No significant difference was found between the pre- and post-treatment total oxidant status and total antioxidant capacity in the groups. Discussion Ibuprofen treatment does not change the total oxidant status or total antioxidant capacity. We believe that the effect of ibuprofen treatment in inducing ischaemia overcomes the scavenging effect of ibuprofen.
- Subjects :
- Administration, Oral
Anti-Inflammatory Agents, Non-Steroidal administration & dosage
Antioxidants metabolism
Biomarkers blood
Dose-Response Relationship, Drug
Ductus Arteriosus, Patent blood
Female
Follow-Up Studies
Gestational Age
Humans
Infant, Newborn
Infusions, Intravenous
Male
Prospective Studies
Ductus Arteriosus, Patent drug therapy
Ibuprofen administration & dosage
Infant, Premature
Oxidative Stress drug effects
Reactive Oxygen Species blood
Subjects
Details
- Language :
- English
- ISSN :
- 1467-1107
- Volume :
- 27
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Cardiology in the young
- Publication Type :
- Academic Journal
- Accession number :
- 27319277
- Full Text :
- https://doi.org/10.1017/S1047951116000822