Back to Search
Start Over
FLUOCINOLONE ACETONIDE IMPLANT FOR VOGT-KOYANAGI-HARADA DISEASE: Three-Year Outcomes of Efficacy and Safety.
- Source :
-
Retina (Philadelphia, Pa.) [Retina] 2016 Nov; Vol. 36 (11), pp. 2124-2131. - Publication Year :
- 2016
-
Abstract
- Purpose: To investigate the efficacy and safety of fluocinolone acetonide intravitreal implant in patients with Vogt-Koyanagi-Harada disease.<br />Methods: A post hoc, subgroup analysis on patients with Vogt-Koyanagi-Harada was performed using data sets from two multicenter randomized trials on fluocinolone acetonide implant. Each subject received fluocinolone acetonide implantation in one eye and standard-of-care treatment in the fellow eye and was followed for 3 years.<br />Results: Thirty patients were included with the mean age of 38.5 years. The cumulative rate of uveitis recurrence for 3 years was significantly reduced in implanted eyes compared with fellow eyes (33 vs. 87%; P < 0.001). The reduction of daily corticosteroid dose was well maintained (12.8 mg before implantation vs. 3.7 mg after implantation; P = 0.001), but final vision was similar to preoperative vision in the implanted eyes (P = 0.082) and in the fellow eyes (P = 0.187). Postoperative elevation of intraocular pressure was more frequent in the implanted eyes than in the fellow eyes (70 vs. 20%; P < 0.001). Cataract progression occurred in all phakic implanted eyes.<br />Conclusion: Fluocinolone acetonide intravitreal implant reduced uveitis recurrence rate and the dosage of systemic corticosteroid and immunosuppressant requirement in patients with Vogt-Koyanagi-Harada. However, cataract and intraocular pressure elevation developed frequently.
- Subjects :
- Adolescent
Adult
Aged
Double-Blind Method
Drug Implants
Female
Fluocinolone Acetonide adverse effects
Follow-Up Studies
Glucocorticoids adverse effects
Humans
Intraocular Pressure drug effects
Intravitreal Injections
Male
Middle Aged
Recurrence
Retrospective Studies
Treatment Outcome
Fluocinolone Acetonide administration & dosage
Glucocorticoids administration & dosage
Uveomeningoencephalitic Syndrome drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1539-2864
- Volume :
- 36
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Retina (Philadelphia, Pa.)
- Publication Type :
- Academic Journal
- Accession number :
- 27333235
- Full Text :
- https://doi.org/10.1097/IAE.0000000000001094