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Neoadjuvant Intraarterial Chemotherapy for Treatment of Malignant Vaginal Tumors in Children: A Single-Center Experience.
- Source :
-
Journal of vascular and interventional radiology : JVIR [J Vasc Interv Radiol] 2016 Jul; Vol. 27 (7), pp. 996-1000. - Publication Year :
- 2016
-
Abstract
- Six patients (aged 3-36 mo) with vaginal tumors (rhabdomyosarcoma and endodermal sinus tumor [EST]; n = 3 each) received intraarterial chemotherapy (IAC) and intravenous chemotherapy. Patients underwent internal iliac artery infusion with cisplatin, pirarubicin, and vindesine. Intravenous chemotherapy with vindesine, ifosfamide, and etoposide was administered after 3 weeks. Vaginal tumors disappeared in all patients after 2 or 3 cycles of alternating therapy. Two patients underwent resection of pelvic metastases. Intravenous consolidation chemotherapy was applied. Four patients were disease-free at a median follow-up of 5.8 years. One patient had pelvic recurrence treated with "salvage" therapy with IAC and surgery and was disease-free for 2.5 years.<br /> (Copyright © 2016 SIR. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Antineoplastic Combined Chemotherapy Protocols adverse effects
Biopsy
Child, Preschool
China
Cisplatin administration & dosage
Disease-Free Survival
Doxorubicin administration & dosage
Doxorubicin analogs & derivatives
Drug Administration Schedule
Endodermal Sinus Tumor diagnostic imaging
Endodermal Sinus Tumor secondary
Endodermal Sinus Tumor surgery
Etoposide administration & dosage
Female
Humans
Ifosfamide administration & dosage
Iliac Artery
Infant
Infusions, Intra-Arterial
Infusions, Intravenous
Metastasectomy
Pelvic Neoplasms drug therapy
Pelvic Neoplasms secondary
Pelvic Neoplasms surgery
Retrospective Studies
Rhabdomyosarcoma, Embryonal diagnostic imaging
Rhabdomyosarcoma, Embryonal secondary
Rhabdomyosarcoma, Embryonal surgery
Time Factors
Tomography, X-Ray Computed
Treatment Outcome
Vaginal Neoplasms diagnostic imaging
Vaginal Neoplasms pathology
Vindesine administration & dosage
Antineoplastic Combined Chemotherapy Protocols administration & dosage
Endodermal Sinus Tumor drug therapy
Neoadjuvant Therapy
Rhabdomyosarcoma, Embryonal drug therapy
Vaginal Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1535-7732
- Volume :
- 27
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of vascular and interventional radiology : JVIR
- Publication Type :
- Academic Journal
- Accession number :
- 27338497
- Full Text :
- https://doi.org/10.1016/j.jvir.2016.03.025