DNA Damage and Aging Around the Clock.

Authors :: Gutierrez-Martinez P
Rossi DJ
Beerman I
Source :: Trends in molecular medicine [Trends Mol Med] 2016 Aug; Vol. 22 (8), pp. 635-637. Date of Electronic Publication: 2016 Jun 23.
Publication Year :: 2016
Abstract: The hematopoietic system undergoes many changes during aging, but the causes and molecular mechanisms behind these changes are not well understood. Wang et al. have recently implicated a circadian rhythm gene, Per2, as playing a role in the DNA damage response and in the expression of lymphoid genes in aged hematopoietic stem cells.<br /> (Copyright © 2016 Elsevier Ltd. All rights reserved.)