Back to Search Start Over

Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax.

Authors :
Hupalo DN
Luo Z
Melnikov A
Sutton PL
Rogov P
Escalante A
Vallejo AF
Herrera S
Arévalo-Herrera M
Fan Q
Wang Y
Cui L
Lucas CM
Durand S
Sanchez JF
Baldeviano GC
Lescano AG
Laman M
Barnadas C
Barry A
Mueller I
Kazura JW
Eapen A
Kanagaraj D
Valecha N
Ferreira MU
Roobsoong W
Nguitragool W
Sattabonkot J
Gamboa D
Kosek M
Vinetz JM
González-Cerón L
Birren BW
Neafsey DE
Carlton JM
Source :
Nature genetics [Nat Genet] 2016 Aug; Vol. 48 (8), pp. 953-8. Date of Electronic Publication: 2016 Jun 27.
Publication Year :
2016

Abstract

Plasmodium vivax is a major public health burden, responsible for the majority of malaria infections outside Africa. We explored the impact of demographic history and selective pressures on the P. vivax genome by sequencing 182 clinical isolates sampled from 11 countries across the globe, using hybrid selection to overcome human DNA contamination. We confirmed previous reports of high genomic diversity in P. vivax relative to the more virulent Plasmodium falciparum species; regional populations of P. vivax exhibited greater diversity than the global P. falciparum population, indicating a large and/or stable population. Signals of natural selection suggest that P. vivax is evolving in response to antimalarial drugs and is adapting to regional differences in the human host and the mosquito vector. These findings underline the variable epidemiology of this parasite species and highlight the breadth of approaches that may be required to eliminate P. vivax globally.

Details

Language :
English
ISSN :
1546-1718
Volume :
48
Issue :
8
Database :
MEDLINE
Journal :
Nature genetics
Publication Type :
Academic Journal
Accession number :
27348298
Full Text :
https://doi.org/10.1038/ng.3588