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Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax.
- Source :
-
Nature genetics [Nat Genet] 2016 Aug; Vol. 48 (8), pp. 953-8. Date of Electronic Publication: 2016 Jun 27. - Publication Year :
- 2016
-
Abstract
- Plasmodium vivax is a major public health burden, responsible for the majority of malaria infections outside Africa. We explored the impact of demographic history and selective pressures on the P. vivax genome by sequencing 182 clinical isolates sampled from 11 countries across the globe, using hybrid selection to overcome human DNA contamination. We confirmed previous reports of high genomic diversity in P. vivax relative to the more virulent Plasmodium falciparum species; regional populations of P. vivax exhibited greater diversity than the global P. falciparum population, indicating a large and/or stable population. Signals of natural selection suggest that P. vivax is evolving in response to antimalarial drugs and is adapting to regional differences in the human host and the mosquito vector. These findings underline the variable epidemiology of this parasite species and highlight the breadth of approaches that may be required to eliminate P. vivax globally.
- Subjects :
- Antimalarials pharmacology
Humans
Malaria, Vivax drug therapy
Malaria, Vivax genetics
Plasmodium vivax drug effects
Plasmodium vivax pathogenicity
Selection, Genetic drug effects
Drug Resistance genetics
Genetic Markers genetics
Malaria, Vivax parasitology
Metagenomics methods
Plasmodium vivax genetics
Selection, Genetic genetics
Transcriptome genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1546-1718
- Volume :
- 48
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Nature genetics
- Publication Type :
- Academic Journal
- Accession number :
- 27348298
- Full Text :
- https://doi.org/10.1038/ng.3588