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Apathy associated with neurocognitive disorders: Recent progress and future directions.
- Source :
-
Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2017 Jan; Vol. 13 (1), pp. 84-100. Date of Electronic Publication: 2016 Jun 27. - Publication Year :
- 2017
-
Abstract
- Introduction: Apathy is common in neurocognitive disorders (NCDs) such as Alzheimer's disease and mild cognitive impairment. Although the definition of apathy is inconsistent in the literature, apathy is primarily defined as a loss of motivation and decreased interest in daily activities.<br />Methods: The Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART) Neuropsychiatric Syndromes Professional Interest Area (NPS-PIA) Apathy workgroup reviewed the latest research regarding apathy in NCDs.<br />Results: Progress has recently been made in three areas relevant to apathy: (1) phenomenology, including the use of diagnostic criteria and novel instruments for measurement, (2) neurobiology, including neuroimaging, neuropathological and biomarker correlates, and (3) interventions, including pharmacologic, nonpharmacologic, and noninvasive neuromodulatory approaches.<br />Discussion: Recent progress confirms that apathy has a significant impact on those with major NCD and those with mild NCDs. As such, it is an important target for research and intervention.<br /> (Copyright © 2016 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Brain diagnostic imaging
Depression diagnostic imaging
Depression epidemiology
Depression etiology
Humans
Neurobiology
Neurocognitive Disorders diagnostic imaging
Neurocognitive Disorders genetics
Neuroimaging
Neuropsychological Tests
Apathy
Neurocognitive Disorders epidemiology
Neurocognitive Disorders psychology
Subjects
Details
- Language :
- English
- ISSN :
- 1552-5279
- Volume :
- 13
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Alzheimer's & dementia : the journal of the Alzheimer's Association
- Publication Type :
- Academic Journal
- Accession number :
- 27362291
- Full Text :
- https://doi.org/10.1016/j.jalz.2016.05.008