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[Use of levosimendan in children].

Authors :
Séguéla PE
Tafer N
Thambo JB
Mauriat P
Source :
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie [Arch Pediatr] 2016 Aug; Vol. 23 (8), pp. 848-56. Date of Electronic Publication: 2016 Jun 29.
Publication Year :
2016

Abstract

Levosimendan is a calcium-sensitizing drug with positive inotropic properties. As an inodilator, this molecule also has a vasodilation effect. While its efficacy has been demonstrated in the adult in the context of cardiac surgery, its pediatric use is still not widespread. Many studies have shown its safety of use in children, including in the newborn. Across the world, a growing number of teams use levosimendan to treat both acute and chronic heart failure. Through a review of the literature, we describe its pharmacodynamic effects, its current applications, and its perspectives of use in children.<br /> (Copyright © 2016 Elsevier Masson SAS. All rights reserved.)

Details

Language :
French
ISSN :
1769-664X
Volume :
23
Issue :
8
Database :
MEDLINE
Journal :
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie
Publication Type :
Academic Journal
Accession number :
27369103
Full Text :
https://doi.org/10.1016/j.arcped.2016.05.002