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Temporal patterns of 18 F-fluorodeoxyglucose positron emission tomography/computed tomography sinonasal uptake after treatment of sinonasal malignancy.
- Source :
-
International forum of allergy & rhinology [Int Forum Allergy Rhinol] 2016 Dec; Vol. 6 (12), pp. 1301-1307. Date of Electronic Publication: 2016 Jul 07. - Publication Year :
- 2016
-
Abstract
- Background: Current guidelines have identified 10 to 12 weeks posttreatment as the ideal time-point for improved diagnostic accuracy of positron emission tomography/computed tomography (PET/CT) for deep tissue sites of the head and neck. After treatment, the sinonasal skull base is predisposed to prolonged inflammation that may render this time-point inappropriate for initial posttreatment imaging surveillance for sinonasal malignancies. The purpose of this study is to evaluate temporal trends in <superscript>18</superscript> F-fluorodeoxyglucose ( <superscript>18</superscript> FDG) sinonasal uptake after treatment for sinonasal malignancies to better elucidate the optimal time-point for initial PET/CT posttreatment evaluation in this patient population.<br />Methods: A retrospective analysis of all successfully treated and non-locally recurrent sinonasal malignancies over a 15-year study period (2000 to 2015) was performed at our institution. Posttreatment <superscript>18</superscript> FDG PET/CT standardized uptake value data were collected and compared between various time-points (2 to 4 months, 5 to 12 months, 5 to 24 months, and 13 to 24 months) using an independent-samples t test.<br />Results: A statistically significant difference was noted between the posttreatment time windows 2 to 4 and 5 to 12 months (p = 0.048) as well as 2 to 4 and 5 to 24 months (p = 0.02). A trend toward significance was seen when comparing 2 to 4 and 13 to 24 months (p = 0.083).<br />Conclusion: Our analysis of PET/CT in patients previously treated for sinonasal malignancy suggests that the posttreatment sinonasal skull base is characterized by a prolonged period of hypermetabolism that endures beyond the period previously described for deep tissue sites of the head and neck. These findings prompt a reevaluation of the previously described 10- to 12-week cutoff point for initial posttreatment PET/CT for head and neck squamous cell carcinoma as applied to sinonasal malignancies.<br /> (© 2016 ARS-AAOA, LLC.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Female
Humans
Male
Middle Aged
Paranasal Sinus Neoplasms metabolism
Paranasal Sinus Neoplasms therapy
Paranasal Sinuses diagnostic imaging
Positron Emission Tomography Computed Tomography
Retrospective Studies
Fluorodeoxyglucose F18 pharmacokinetics
Paranasal Sinuses metabolism
Radiopharmaceuticals pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 2042-6984
- Volume :
- 6
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- International forum of allergy & rhinology
- Publication Type :
- Academic Journal
- Accession number :
- 27383662
- Full Text :
- https://doi.org/10.1002/alr.21814