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The microbiome and innate immunity.
- Source :
-
Nature [Nature] 2016 Jul 07; Vol. 535 (7610), pp. 65-74. - Publication Year :
- 2016
-
Abstract
- The intestinal microbiome is a signalling hub that integrates environmental inputs, such as diet, with genetic and immune signals to affect the host's metabolism, immunity and response to infection. The haematopoietic and non-haematopoietic cells of the innate immune system are located strategically at the host-microbiome interface. These cells have the ability to sense microorganisms or their metabolic products and to translate the signals into host physiological responses and the regulation of microbial ecology. Aberrations in the communication between the innate immune system and the gut microbiota might contribute to complex diseases.
- Subjects :
- Animals
Autoimmunity
Epigenesis, Genetic
Gastrointestinal Microbiome immunology
Humans
Immunity, Innate genetics
Immunity, Innate immunology
Infections genetics
Infections immunology
Infections microbiology
Inflammation genetics
Inflammation microbiology
Inflammation pathology
Intestinal Mucosa cytology
Intestinal Mucosa microbiology
Intestinal Mucosa physiology
Lymphocytes physiology
Metabolic Syndrome metabolism
Metabolic Syndrome microbiology
Metabolic Syndrome pathology
Myeloid Cells physiology
Neoplasms genetics
Neoplasms microbiology
Neoplasms pathology
Gastrointestinal Microbiome physiology
Immunity, Innate physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1476-4687
- Volume :
- 535
- Issue :
- 7610
- Database :
- MEDLINE
- Journal :
- Nature
- Publication Type :
- Academic Journal
- Accession number :
- 27383981
- Full Text :
- https://doi.org/10.1038/nature18847