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The Drosophila neurogenin Tap functionally interacts with the Wnt-PCP pathway to regulate neuronal extension and guidance.
- Source :
-
Development (Cambridge, England) [Development] 2016 Aug 01; Vol. 143 (15), pp. 2760-6. Date of Electronic Publication: 2016 Jul 06. - Publication Year :
- 2016
-
Abstract
- The neurogenin (Ngn) transcription factors control early neurogenesis and neurite outgrowth in mammalian cortex. In contrast to their proneural activity, their function in neurite growth is poorly understood. Drosophila has a single predicted Ngn homolog, Tap, of unknown function. Here we show that Tap is not a proneural protein in Drosophila but is required for proper axonal growth and guidance of neurons of the mushroom body, a neuropile required for associative learning and memory. Genetic and expression analyses suggest that Tap inhibits excessive axonal growth by fine regulation of the levels of the Wnt signaling adaptor protein Dishevelled.<br />Competing Interests: The authors declare no competing or financial interests.<br /> (© 2016. Published by The Company of Biologists Ltd.)
- Subjects :
- Adaptor Proteins, Signal Transducing genetics
Adaptor Proteins, Signal Transducing metabolism
Animals
Axon Guidance genetics
Axon Guidance physiology
Axons metabolism
Cell Polarity genetics
Drosophila
Drosophila Proteins genetics
Mushroom Bodies metabolism
Neuropeptides genetics
Protein Binding
Transcription Factors genetics
Wnt Signaling Pathway genetics
Cell Polarity physiology
Drosophila Proteins metabolism
Neuropeptides metabolism
Transcription Factors metabolism
Wnt Signaling Pathway physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1477-9129
- Volume :
- 143
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Development (Cambridge, England)
- Publication Type :
- Academic Journal
- Accession number :
- 27385016
- Full Text :
- https://doi.org/10.1242/dev.134155