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Immunoglobulin A deficiency following treatment with lamotrigine.
- Source :
-
Brain & development [Brain Dev] 2016 Nov; Vol. 38 (10), pp. 947-949. Date of Electronic Publication: 2016 Jul 07. - Publication Year :
- 2016
-
Abstract
- Lamotrigine (LTG) is an anti-epileptic drug and mood-stabilizing agent, whose adverse effects include skin rash and dizziness. Interactions with the immune system are rare, and only a few cases linking hypogammaglobulinemia to LTG treatment have been previously described. In this report, we describe a case in which a patient developed hypogammaglobulinemia, and a subsequent immunoglobulin A (IgA) deficiency, following LTG treatment. As a result of her immunodeficiency, the patient presented with a severe urinary tract infection and required intravenous immunoglobulin. Serum levels of immunoglobulin G and M had recovered by seven months and one month after the discontinuation of LTG, respectively; however, IgA levels remained low (less than 4mg/dL) two years post-treatment. While previous reports have demonstrated IgA deficiencies in patients prescribed other antiepileptic drugs, this is the first case of an IgA deficiency following LTG administration.<br /> (Copyright © 2016 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Adolescent
Anticonvulsants therapeutic use
Common Variable Immunodeficiency blood
Epilepsy blood
Epilepsy drug therapy
Female
Humans
IgA Deficiency blood
Immunoglobulin A blood
Lamotrigine
Triazines therapeutic use
Anticonvulsants adverse effects
Common Variable Immunodeficiency chemically induced
IgA Deficiency chemically induced
Triazines adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7131
- Volume :
- 38
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Brain & development
- Publication Type :
- Academic Journal
- Accession number :
- 27396372
- Full Text :
- https://doi.org/10.1016/j.braindev.2016.06.006