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Expression of osteoprotegerin and its ligands, RANKL and TRAIL, in rheumatoid arthritis.
- Source :
-
Scientific reports [Sci Rep] 2016 Jul 12; Vol. 6, pp. 29713. Date of Electronic Publication: 2016 Jul 12. - Publication Year :
- 2016
-
Abstract
- Osteoprotegerin (OPG), receptor activator of nuclear factor-ΚB ligand (RANKL) and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) have been involved in rheumatoid arthritis (RA) pathophysiology. In this study, we assessed messenger RNA (mRNA) expression of these molecules by qPCR in peripheral blood from 26 patients with RA (12 of them with ischemic heart disease -IHD) and 10 healthy controls. Correlation coefficients between OPG, RANKL and TRAIL expression levels in RA patients and their clinical and demographic characteristics were also evaluated. Whereas OPG and OPG/TRAIL ratio expression were significantly increased in RA patients compared to controls (fold change = 1.79, p = 0.013 and 2.07, p = 0.030, respectively), RANKL/OPG ratio was significantly decreased (fold change = 0.50, p = 0.020). No significant differences were found between patients and controls in RANKL and TRAIL expression. Interestingly, TRAIL expression was significantly higher in RA patients with IHD compared to those without IHD (fold change = 1.46, p = 0.033). Moreover, biologic disease-modifying antirheumatic drugs (DMARDs) significantly decreased RANKL expression in RA patients (p = 0.016). Our study supports an important role of OPG and TRAIL in RA. Furthermore, it highlights an effect of biologic DMARDs in the modulation of RANKL.
- Subjects :
- Antirheumatic Agents administration & dosage
Arthritis, Rheumatoid drug therapy
Arthritis, Rheumatoid pathology
Female
Humans
Male
Myocardial Ischemia blood
Myocardial Ischemia drug therapy
Myocardial Ischemia pathology
Arthritis, Rheumatoid blood
Gene Expression Regulation
Osteoprotegerin blood
RANK Ligand blood
TNF-Related Apoptosis-Inducing Ligand blood
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 6
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 27403809
- Full Text :
- https://doi.org/10.1038/srep29713