Back to Search
Start Over
Gastrointestinal Symptoms in Celiac Disease Patients on a Long-Term Gluten-Free Diet.
- Source :
-
Nutrients [Nutrients] 2016 Jul 14; Vol. 8 (7). Date of Electronic Publication: 2016 Jul 14. - Publication Year :
- 2016
-
Abstract
- Experience suggests that many celiac patients suffer from persistent symptoms despite a long-term gluten-free diet (GFD). We investigated the prevalence and severity of these symptoms in patients with variable duration of GFD. Altogether, 856 patients were classified into untreated (n = 128), short-term GFD (1-2 years, n = 93) and long-term GFD (≥3 years, n = 635) groups. Analyses were made of clinical and histological data and dietary adherence. Symptoms were evaluated by the validated GSRS questionnaire. One-hundred-sixty healthy subjects comprised the control group. Further, the severity of symptoms was compared with that in peptic ulcer, reflux disease, inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Altogether, 93% of the short-term and 94% of the long-term treated patients had a strict GFD and recovered mucosa. Untreated patients had more diarrhea, indigestion and abdominal pain than those on GFD and controls. There were no differences in symptoms between the short- and long-term GFD groups, but both yielded poorer GSRS total score than controls (p = 0.03 and p = 0.05, respectively). Furthermore, patients treated 1-2 years had more diarrhea (p = 0.03) and those treated >10 years more reflux (p = 0.04) than controls. Long-term treated celiac patients showed relatively mild symptoms compared with other gastrointestinal diseases. Based on our results, good response to GFD sustained in long-term follow-up, but not all patients reach the level of healthy individuals.
- Subjects :
- Abdominal Pain epidemiology
Abdominal Pain prevention & control
Adolescent
Adult
Aged
Aged, 80 and over
Celiac Disease diagnosis
Celiac Disease epidemiology
Cross-Sectional Studies
Diarrhea epidemiology
Diarrhea prevention & control
Dyspepsia epidemiology
Dyspepsia prevention & control
Female
Finland epidemiology
Gastroesophageal Reflux complications
Humans
Inflammatory Bowel Diseases complications
Irritable Bowel Syndrome complications
Male
Middle Aged
Patient Compliance
Peptic Ulcer complications
Prevalence
Retrospective Studies
Surveys and Questionnaires
Time Factors
Treatment Outcome
Young Adult
Celiac Disease diet therapy
Diet, Gluten-Free
Subjects
Details
- Language :
- English
- ISSN :
- 2072-6643
- Volume :
- 8
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Nutrients
- Publication Type :
- Academic Journal
- Accession number :
- 27428994
- Full Text :
- https://doi.org/10.3390/nu8070429