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Cutting Edge: B Cell-Intrinsic T-bet Expression Is Required To Control Chronic Viral Infection.
- Source :
-
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2016 Aug 15; Vol. 197 (4), pp. 1017-22. Date of Electronic Publication: 2016 Jul 18. - Publication Year :
- 2016
-
Abstract
- The role of Ab and B cells in preventing infection is established. In contrast, the role of B cell responses in containing chronic infections remains poorly understood. IgG2a (IgG1 in humans) can prevent acute infections, and T-bet promotes IgG2a isotype switching. However, whether IgG2a and B cell-expressed T-bet influence the host-pathogen balance during persisting infections is unclear. We demonstrate that B cell-specific loss of T-bet prevents control of persisting viral infection. T-bet in B cells controlled IgG2a production, as well as mucosal localization, proliferation, glycosylation, and a broad transcriptional program. T-bet controlled a broad antiviral program in addition to IgG2a because T-bet in B cells was important, even in the presence of virus-specific IgG2a. Our data support a model in which T-bet is a universal controller of antiviral immunity across multiple immune lineages.<br /> (Copyright © 2016 by The American Association of Immunologists, Inc.)
- Subjects :
- Animals
Cell Separation
Chronic Disease
Disease Models, Animal
Enzyme-Linked Immunosorbent Assay
Flow Cytometry
Immunoglobulin G immunology
Lymphocytic choriomeningitis virus
Mice
Mice, Transgenic
Oligonucleotide Array Sequence Analysis
B-Lymphocyte Subsets immunology
B-Lymphocytes immunology
Lymphocytic Choriomeningitis immunology
T-Box Domain Proteins immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1550-6606
- Volume :
- 197
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of immunology (Baltimore, Md. : 1950)
- Publication Type :
- Academic Journal
- Accession number :
- 27430722
- Full Text :
- https://doi.org/10.4049/jimmunol.1500368