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DABCO-catalyzed one-pot three component synthesis of dihydropyrano[3,2-c]chromene substituted quinazolines and their evaluation towards anticancer activity.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2016 Aug 15; Vol. 26 (16), pp. 3973-7. Date of Electronic Publication: 2016 Jul 07. - Publication Year :
- 2016
-
Abstract
- A facile DABCO promoted one-pot three component synthesis of a new series of C-C linked bis-heterocycle containing dihydropyrano[c]chromene as highly fused oxa-heteryl group at C-2 position of quinazoline was developed. Quinazoline-2-carbaldehyde, substituted 4-hydroxycoumarin and ethyl cyanoacetate were used as key components in the Knoevenagel-Michael addition reaction to get the titled compounds. These compounds were screened for anti-cancer activity against the breast cancer cell lines of MDA-MB 231, and MDA-MB 453.<br /> (Copyright © 2016 Elsevier Ltd. All rights reserved.)
- Subjects :
- Antineoplastic Agents metabolism
Antineoplastic Agents toxicity
Binding Sites
Catalysis
Catalytic Domain
Cell Line, Tumor
Cell Survival drug effects
Estrogen Receptor alpha chemistry
Estrogen Receptor alpha metabolism
Humans
Hydrogen Bonding
Molecular Docking Simulation
Thermodynamics
Antineoplastic Agents chemical synthesis
Benzopyrans chemistry
Piperazines chemistry
Quinazolines chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 26
- Issue :
- 16
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 27432765
- Full Text :
- https://doi.org/10.1016/j.bmcl.2016.07.003