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Serum carbohydrate antigen 125 concentration as a superior predictor for serosal effusion at diagnosis and a prognostic factor in diffuse large B-cell lymphoma.
- Source :
-
Cancer biomarkers : section A of Disease markers [Cancer Biomark] 2016 Jul 08; Vol. 17 (2), pp. 205-12. - Publication Year :
- 2016
-
Abstract
- Background: Carbohydrate antigen 125 (CA-125) is one of the most common used tumor biomarkers in clinical practice. Previous studies showed an association of increased CA-125 levels with advanced characteristics and inferior outcome in non-Hodgkin lymphoma.<br />Objective: To identify the clinical significance of CA-125 in diffuse large B-cell lymphoma (DLBCL).<br />Methods: We retrospectively analyzed 181 patients with DLBCL with measured serum CA-125 concentration at diagnosis and follow-ups during the courses. Clinical significance of CA-125 was evaluated by assessing the association between CA-125 levels and clinical characteristics.<br />Results: CA-125 levels on admission were positively correlated with serum lactate dehydrogenase, β2-microglobulin (β2-MG), serum ferritin (SF) and cavity effusion, while negatively correlated with serum albumen (ALB). During the courses, CA-125 levels were positively correlated with β 2-MG, SF and effusion, and negatively correlated with ALB. A better correlation between effusion and CA-125 levels was observed. Using a cut-off value > 50.39 U/ml gave a sensitivity of 73.8% and a specificity of 92.1% for the indication of effusion at diagnosis, while during the courses the sensitivity was much lower. On the prognostic role of CA-125, we found prognostic relevance on progression-free survival (PFS) but not on overall survival (OS).<br />Conclusions: Our study revealed limited usefulness of CA-125 concentration at diagnosis and follow-ups in DLBCL.
- Subjects :
- Adult
Aged
Female
Humans
Lymphoma, Large B-Cell, Diffuse drug therapy
Lymphoma, Large B-Cell, Diffuse mortality
Lymphoma, Primary Effusion drug therapy
Lymphoma, Primary Effusion mortality
Male
Middle Aged
Neoplasm Staging
Prognosis
Retrospective Studies
Survival Analysis
Biomarkers, Tumor
CA-125 Antigen blood
Lymphoma, Large B-Cell, Diffuse blood
Lymphoma, Large B-Cell, Diffuse diagnosis
Lymphoma, Primary Effusion blood
Lymphoma, Primary Effusion diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1875-8592
- Volume :
- 17
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cancer biomarkers : section A of Disease markers
- Publication Type :
- Academic Journal
- Accession number :
- 27434288
- Full Text :
- https://doi.org/10.3233/CBM-160632