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CD151 expression is frequent but unrelated to clinical outcome in head and neck cancer.
- Source :
-
Clinical oral investigations [Clin Oral Investig] 2017 Jun; Vol. 21 (5), pp. 1503-1508. Date of Electronic Publication: 2016 Jul 21. - Publication Year :
- 2017
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Abstract
- Objectives: CD151 is a plasma membrane protein belonging to the tetraspanin family. CD151 represents a putative therapeutic target and has been suggested as a prognostic marker in several cancer types. The present study aims to investigate the prognostic relevance of immunohistochemical CD151 expression in head and neck squamous cell carcinoma (HNSCC).<br />Materials and Methods: Tissue microarray (TMA) sections containing samples from 667 cancers of oral cavity, oro- and hypopharynx and larynx, for which follow-up data were available, were analyzed for CD151 expression by immunohistochemistry.<br />Results: Membranous CD151 immunostaining was recorded in 269 (60.3 %) of 446 analyzable cases. Staining was considered weak in 129 (28.9 %), moderate in 98 (22.0 %), and strong in 42 (9.4 %) of cancers. CD151 expression was unrelated to histological grade, tumor stage, nodal status, or surgical margin. There was a tendency towards a somewhat lower prevalence of CD151 expression in tumors of the oral cavity (52.9 % positive) as compared to cancers of the oro-hypopharynx (62.1 %) and larynx (63.3 %; p = 0.0100). CD151 expression had no impact on patient survival.<br />Clinical Relevance: In summary, immunohistochemical analysis of CD151 lacks prognostic utility in HNSCC. The high prevalence of CD151 expression in HNSCC emphasizes its putative relevance as a therapeutic target for further development of anti-CD151 drugs.
Details
- Language :
- English
- ISSN :
- 1436-3771
- Volume :
- 21
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Clinical oral investigations
- Publication Type :
- Academic Journal
- Accession number :
- 27444451
- Full Text :
- https://doi.org/10.1007/s00784-016-1911-3