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Accelerated corneal crosslinking for treatment of progressive keratoconus in pediatric patients.
- Source :
-
European journal of ophthalmology [Eur J Ophthalmol] 2017 May 11; Vol. 27 (3), pp. 319-325. Date of Electronic Publication: 2016 Jul 20. - Publication Year :
- 2017
-
Abstract
- Purpose: To evaluate the safety and efficacy of accelerated corneal crosslinking (CXL) in patients with progressive keratoconus aged 18 years or less.<br />Methods: A total of 28 eyes from 19 patients with progressive keratoconus aged 18 years or less were enrolled. We divided participants into 2 groups according to corneal thickness (CT). Group 1 included 13 eyes of 8 patients with CT ≥450 µm; group 2 included 15 eyes of 11 patients with CT <450 µm. Each participant underwent accelerated CXL using 10-minute ultraviolet A irradiance at 9 mW/cm2 for a total energy dose of 5.4 J/cm2. The efficacy and safety of the procedure were assessed postoperatively at 1, 3, 6, and 12 months with Pentacam and visual acuity.<br />Results: In uncorrected visual acuity, group 1 showed a statistically significant +0.12 logMAR improvement at 3 months postoperatively (p = 0.003), and in group 2, there was a statistically significant +0.3 logMAR improvement at 1 month postoperatively (p = 0.005). In best-corrected visual acuity, there was a +0.15 logMAR (p<0.001) and +0.22 logMAR (p = 0.005) improvement in group 1 and group 2, respectively, at 12 months postoperatively. All mean keratometric values including K1 and K2 dropped by at least 1 D or remained stable (< ± 1 D) in both groups after accelerated CXL treatment.<br />Conclusions: The findings showed that accelerated CXL treatment seems to be effective in slowing or halting the progression of keratoconus and that no permanent apparent complications are noted 6 months after accelerated CXL.
- Subjects :
- Adolescent
Child
Corneal Topography
Cross-Sectional Studies
Disease Progression
Female
Humans
Keratoconus pathology
Male
Photosensitizing Agents therapeutic use
Young Adult
Collagen therapeutic use
Corneal Transplantation methods
Cross-Linking Reagents therapeutic use
Keratoconus therapy
Photochemotherapy methods
Visual Acuity
Subjects
Details
- Language :
- English
- ISSN :
- 1724-6016
- Volume :
- 27
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- European journal of ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 27445064
- Full Text :
- https://doi.org/10.5301/ejo.5000848