Versicones E-H and arugosin K produced by the mangrove-derived fungus Aspergillus versicolor HDN11-84.

Authors :: Li F
Guo W
Che Q
Zhu T
Gu Q
Li D
Source :: The Journal of antibiotics [J Antibiot (Tokyo)] 2017 Feb; Vol. 70 (2), pp. 174-178. Date of Electronic Publication: 2016 Jul 27.
Publication Year :: 2017
Abstract: Four new xanthonoids, versicones E-H (1-4), and a biogenetically related new derivative arugosin K (5), were isolated from a culture extract of the mangrove-derived fungus Aspergillus versicolor HDN11-84. Their structures were elucidated on the basis of extensive NMR spectroscopic data analysis. Versicone E (1) represents the first example of naturally occurring xanthonoids containing a 2-butenamide moiety. Among them, 5 showed the best cytotoxicity against Hela cell line with an IC <subscript>50</subscript> value of 9.2 μm.

Subjects :: Antineoplastic Agents chemistry
Antineoplastic Agents metabolism
Antineoplastic Agents pharmacology
Benzopyrans chemistry
Benzopyrans pharmacology
Benzoxepins chemistry
Benzoxepins pharmacology
Cell Line, Tumor
Humans
Molecular Structure
Xanthones chemistry
Xanthones pharmacology
Aspergillus classification
Aspergillus metabolism
Benzopyrans metabolism
Benzoxepins metabolism
Xanthones metabolism

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