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Preoperative neutrophil-to-lymphocyte ratio as a predictor of survival after reductive surgery plus percutaneous isolated hepatic perfusion for hepatocellular carcinoma: a retrospective analysis.
- Source :
-
Surgery today [Surg Today] 2017 Mar; Vol. 47 (3), pp. 385-392. Date of Electronic Publication: 2016 Jul 27. - Publication Year :
- 2017
-
Abstract
- Purpose: We assessed the predictive value of the preoperative neutrophil-to-lymphocyte ratio (NLR) in patients who underwent a two-stage treatment combining reductive surgery and percutaneous isolated hepatic perfusion for multiple hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT).<br />Methods: Forty-two patients underwent the two-stage treatment between January 2000 and December 2014 at Kobe University Hospital (Hyogo, Japan). The NLR was calculated from lymphocyte and neutrophil counts in the preoperative routine blood test. Clinical data and overall survival were compared statistically and multivariate analysis was done to identify prognostic factors.<br />Results: The median survival of patients with a preoperative NLR > 2.3 was 14.9 months (n = 13), whereas that of patients with a preoperative NLR ≤ 2.3 was 26.1 months (n = 29; P = 0.022). A preoperative NLR > 2.3 was an independent prognostic factor in patients with multiple HCC with PVTT [hazard ratio (HR) 2.329; 95 % confidence interval (CI) 1.058-5.667; P = 0.036].<br />Conclusion: Based on the results of this study, an elevated preoperative NLR is an independent predictive risk factor for patients undergoing two-stage treatment for multiple HCC with PVTT.
- Subjects :
- Adult
Aged
Aged, 80 and over
Carcinoma, Hepatocellular blood
Combined Modality Therapy mortality
Female
Hepatectomy methods
Humans
Leukocyte Count
Liver Neoplasms blood
Lymphocyte Count
Male
Middle Aged
Multivariate Analysis
Predictive Value of Tests
Preoperative Care
Retrospective Studies
Risk Factors
Survival Rate
Carcinoma, Hepatocellular mortality
Carcinoma, Hepatocellular therapy
Liver Neoplasms mortality
Liver Neoplasms therapy
Lymphocytes
Neutrophils
Perfusion methods
Subjects
Details
- Language :
- English
- ISSN :
- 1436-2813
- Volume :
- 47
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Surgery today
- Publication Type :
- Academic Journal
- Accession number :
- 27465474
- Full Text :
- https://doi.org/10.1007/s00595-016-1384-7