Immunomodulators in the Treatment of Nasal Polyposis.

Authors :: Halderman AA
Lane AP
Source :: Advances in oto-rhino-laryngology [Adv Otorhinolaryngol] 2016; Vol. 79, pp. 103-13. Date of Electronic Publication: 2016 Jul 28.
Publication Year :: 2016
Abstract: The inflammatory mechanisms that contribute to chronic rhinosinusitis with nasal polyps (CRSwNP) are complex. In the past, medical options for treating CRSwNP have been limited. Emerging classes of immunomodulators such as omalizumab, anti-leukotrienes, anti-IL-4, anti-IL-5, and recognition of the modulating effects of macrolides have shown promising results in the treatment of CRSwNP. Ultimately, large randomized controlled trials are necessary to establish the efficacy of these medications but for now, the area of medical immunomodulators remains an exciting frontier.<br /> (© 2016 S. Karger AG, Basel.)