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Non-Linear Pharmacokinetics of Atomoxetine in Adult Japanese Patients With ADHD.
- Source :
-
Journal of attention disorders [J Atten Disord] 2020 Feb; Vol. 24 (3), pp. 490-493. Date of Electronic Publication: 2016 Jul 28. - Publication Year :
- 2020
-
Abstract
- Objective: The objective was to reveal the relationship between dose and concentration of atomoxetine. Method: Fifty-five blood samples of 33 patients with ADHD were examined using high-performance liquid chromatography. Results: The plasma concentrations were 53.2 ± 67.0, 298.0 ± 390.5, and 639.3 ± 831.9 ng/mL at doses of 40 mg, 80 mg, and 120 mg, and the concentration/dose were 1.33 ± 1.67, 3.73 ± 4.88, and 5.33 ± 6.93 ng/mL/mg, respectively. Statistical analyses revealed a significant correlation between the concentration and the dose of atomoxetine ( p = .004), and a trending toward significance in the difference in the concentration/dose in the three dosage groups ( p = .064). The concentration/dose at 40 and 80 + 120 mg/day were 1.33 ± 1.67 and 4.22 ± 5.53 ng/mL/mg, the latter was significantly higher than the former ( p = .006), which suggested non-linear pharmacokinetics. Conclusion: Clinicians should carefully titrate in high dose atomoxetine treatment.
Details
- Language :
- English
- ISSN :
- 1557-1246
- Volume :
- 24
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of attention disorders
- Publication Type :
- Academic Journal
- Accession number :
- 27474159
- Full Text :
- https://doi.org/10.1177/1087054716661235