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Diphenyl diselenide attenuates oxidative stress and inflammatory parameters in ulcerative colitis: A comparison with ebselen.
- Source :
-
Pathology, research and practice [Pathol Res Pract] 2016 Sep; Vol. 212 (9), pp. 755-60. Date of Electronic Publication: 2016 May 02. - Publication Year :
- 2016
-
Abstract
- Objetive: The aim of this study was to evaluate the effects of diphenyl diselenide (PhSe)2 and ebselen (EB) in ulcerative colitis (UC) induced by dextran sulfate sodium (DSS) in rats.<br />Methods: The effects of (PhSe)2 and EB in rats submitted to DSS-induced colitis were determined by measurement of oxidative stress parameters, inflammatory response and bowel histopathological alterations.<br />Results: Animals developed moderate to severe neutrophil infiltration in histopathology assay in DSS rats and (PhSe)2 improved this response. Moreover, the treatment with (PhSe)2 decreased the oxidative damage in lipids and proteins, as well as reversed the superoxide dismutase (SOD) and catalase (CAT) levels in rats treated with DSS. EB was able only to reverse damage in lipids and the low levels of SOD in this animal model.<br />Conclusions: The organoselenium compounds tested demonstrated an anti-inflammatory and antioxidant activity reducing the colon damage, being (PhSe)2 more effective than EB.<br /> (Copyright © 2016 Elsevier GmbH. All rights reserved.)
- Subjects :
- Animals
Azoles pharmacology
Benzene Derivatives pharmacology
Catalase metabolism
Colitis chemically induced
Colitis metabolism
Colon drug effects
Colon metabolism
Disease Models, Animal
Inflammation chemically induced
Inflammation metabolism
Isoindoles
Male
Neutrophils
Organoselenium Compounds pharmacology
Rats
Rats, Wistar
Reactive Oxygen Species metabolism
Superoxide Dismutase metabolism
Azoles therapeutic use
Benzene Derivatives therapeutic use
Colitis drug therapy
Inflammation drug therapy
Organoselenium Compounds therapeutic use
Oxidative Stress drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1618-0631
- Volume :
- 212
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Pathology, research and practice
- Publication Type :
- Academic Journal
- Accession number :
- 27475409
- Full Text :
- https://doi.org/10.1016/j.prp.2016.04.012