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Risk of dementia and death in community-dwelling older men with bipolar disorder.
- Source :
-
The British journal of psychiatry : the journal of mental science [Br J Psychiatry] 2016 Aug; Vol. 209 (2), pp. 121-6. Date of Electronic Publication: 2016 Jun 09. - Publication Year :
- 2016
-
Abstract
- Background: Bipolar disorder has been associated with cognitive decline, but confirmatory evidence from a community-derived sample of older people is lacking.<br />Aims: To investigate the 13-year risk of dementia and death in older adults with bipolar disorder.<br />Method: Cohort study of 37 768 men aged 65-85 years. Dementia (primary) and death (secondary), as recorded by electronic record linkage, were the outcomes of interest.<br />Results: Bipolar disorder was associated with increased adjusted hazard ratio (HR) of dementia (HR = 2.30, 95% CI 1.80-2.94). The risk of dementia was greatest among those with <5 years of history of bipolar disorder or who had had illness onset after 70 years of age. Bipolar disorder was also associated with increased mortality (HR = 1.51, 95% CI 1.28-1.77). Competing risk regression showed that bipolar disorder was associated with increased hazard of death by suicide, accidents, pneumonia or influenza, and diseases of the liver and digestive system.<br />Conclusions: Bipolar disorder in later life is associated with increased risk of dementia and premature death.<br /> (© The Royal College of Psychiatrists 2016.)
Details
- Language :
- English
- ISSN :
- 1472-1465
- Volume :
- 209
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The British journal of psychiatry : the journal of mental science
- Publication Type :
- Academic Journal
- Accession number :
- 27482038
- Full Text :
- https://doi.org/10.1192/bjp.bp.115.180059