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Increased reactivity to histamine in the coronary vascular system of the guinea-pig after endotoxin.
- Source :
-
Agents and actions [Agents Actions] 1989 Apr; Vol. 27 (1-2), pp. 158-9. - Publication Year :
- 1989
-
Abstract
- Histamine produced a dose-dependent increase in heart rate, myocardial contractility and coronary flow in the isolated guinea-pig heart using a modified Langendorff procedure. Intraperitoneal treatment of the guinea pigs with E. coli endotoxin, 4 days prior to the experiment, enhanced the positive chronotropic and flow-increasing effect of histamine. The increased response to histamine appeared to be H1-receptor mediated, the positive chronotropic response is attributed to H2-receptors. These results indicate that bacterial endotoxin increases the reactivity of the coronary vascular system of the guinea-pig to histamine.
Details
- Language :
- English
- ISSN :
- 0065-4299
- Volume :
- 27
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Agents and actions
- Publication Type :
- Academic Journal
- Accession number :
- 2750587
- Full Text :
- https://doi.org/10.1007/BF02222226