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HER2-positive breast cancer targeting and treatment by a peptide-conjugated mini nanodrug.
- Source :
-
Nanomedicine : nanotechnology, biology, and medicine [Nanomedicine] 2017 Feb; Vol. 13 (2), pp. 631-639. Date of Electronic Publication: 2016 Aug 09. - Publication Year :
- 2017
-
Abstract
- HER2+ breast cancer is one of the most aggressive forms of breast cancer. The new polymalic acid-based mini nanodrug copolymers are synthesized and specifically characterized to inhibit growth of HER2+ breast cancer. These mini nanodrugs are highly effective and in the clinic may substitute for trastuzumab (the marketed therapeutic antibody) and antibody-targeted nanobioconjugates. Novel mini nanodrugs are designed to have slender shape and small size. HER2+ cells were recognized by the polymer-attached trastuzumab-mimetic 12-mer peptide. Synthesis of the nascent cell-transmembrane HER2/neu receptors by HER2+ cells was inhibited by antisense oligonucleotides that prevented cancer cell proliferation and significantly reduced tumor size by more than 15 times vs. untreated control or PBS-treated group. We emphasize that the shape and size of mini nanodrugs can enhance penetration of multiple bio-barriers to facilitate highly effective treatment. Replacement of trastuzumab by the mimetic peptide favors reduced production costs and technical efforts, and a negligible immune response.<br /> (Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Antibodies, Monoclonal, Humanized administration & dosage
Cell Line, Tumor
Humans
Nanoparticles chemistry
Peptides therapeutic use
Trastuzumab administration & dosage
Antibodies, Monoclonal, Humanized pharmacokinetics
Breast Neoplasms drug therapy
Receptor, ErbB-2
Trastuzumab pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 1549-9642
- Volume :
- 13
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Nanomedicine : nanotechnology, biology, and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 27520726
- Full Text :
- https://doi.org/10.1016/j.nano.2016.07.013