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Comparative effects of verapamil and nitroprusside on left ventricular function in patients with hypertension.
- Source :
-
Journal of the American College of Cardiology [J Am Coll Cardiol] 1989 Aug; Vol. 14 (2), pp. 515-22. - Publication Year :
- 1989
-
Abstract
- The effects of verapamil were compared with those of nitroprusside at matched mean arterial pressures and heart rates in 10 symptomatic hypertensive patients during cardiac catheterization. Simultaneous radionuclide angiography and micromanometer pressure measurements were obtained to assess left ventricular pressure-volume relations. Compared with control conditions, verapamil increased left ventricular end-diastolic volume index from 57 +/- 16 to 70 +/- 28 ml/m2 (p = 0.05) without a significant increase in left ventricular end-diastolic pressure (from 10 +/- 4 to 13 +/- 6 mm Hg). Despite a downward and rightward shift in the end-systolic pressure-volume relation indicating negative inotropic effects, ejection fraction did not decrease significantly (from 52 +/- 9% to 46 +/- 9%); cardiac index and stroke volume index remained unchanged. The change in stroke volume index with verapamil was directly related to the magnitude of change in end-diastolic volume index (r = 0.82, p less than 0.005), suggesting that the increase in end-diastolic volume did not arise purely from negative inotropic effects. Systemic vascular resistance index decreased from 42 +/- 8 to 34 +/- 7 mm Hg.min.m2/liter (p less than 0.05). In contrast, nitroprusside decreased left ventricular end-diastolic volume index from 57 +/- 16 to 41 +/- 10 ml/m2 (p less than 0.05), cardiac index from 3.2 +/- 0.7 to 2.8 +/- 0.6 liters/min per m2 (p less than 0.05) and stroke volume index from 28 +/- 6 to 24 +/- 5 ml/m2 (p less than 0.01), with no change in systemic vascular resistance index (40 +/- 10 mm Hg.min.m2).(ABSTRACT TRUNCATED AT 250 WORDS)
- Subjects :
- Adult
Cardiac Catheterization
Echocardiography
Female
Heart diagnostic imaging
Humans
Male
Middle Aged
Radionuclide Angiography
Ferricyanides therapeutic use
Hypertension drug therapy
Myocardial Contraction drug effects
Nitroprusside therapeutic use
Stroke Volume drug effects
Verapamil therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0735-1097
- Volume :
- 14
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of the American College of Cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 2754137
- Full Text :
- https://doi.org/10.1016/0735-1097(89)90210-6