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Volume-based quantification using dual-energy computed tomography in the differentiation of thymic epithelial tumours: an initial experience.
- Source :
-
European radiology [Eur Radiol] 2017 May; Vol. 27 (5), pp. 1992-2001. Date of Electronic Publication: 2016 Aug 23. - Publication Year :
- 2017
-
Abstract
- Objectives: To investigate the diagnostic value of dual-energy computed tomography (DECT) in differentiating between low- and high-risk thymomas and thymic carcinomas.<br />Materials: Our institutional review board approved this study, and patients provided informed consent. We prospectively enrolled 37 patients (20 males, mean age: 55.6 years) with thymic epithelial tumour. All patients underwent DECT. For quantitative analysis, two reviewers measured the following tumour parameters: CT attenuation value in contrast Hounsfield units (CHU), iodine-related HU and iodine concentration (mg/ml). Pathological results confirmed the final diagnosis.<br />Results: Of the 37 thymic tumours, 23 (62.2 %) were low-risk thymomas, five (13.5 %) were high-risk thymomas and nine (24.3 %) were thymic carcinomas. According to quantitative analysis, iodine-related HU and iodine concentration were significantly different among low-risk thymomas, high-risk thymomas and thymic carcinomas (median: 29.78 HU vs. 14.55 HU vs. 19.95 HU, p = 0.001 and 1.92 mg/ml vs. 0.99 mg/ml vs. 1.18 mg/ml, p < 0.001, respectively).<br />Conclusion: DECT using a quantitative analytical method based on iodine concentration measurement can be used to differentiate among thymic epithelial tumours using single-phase scanning.<br />Key Points: • IHU and IC were lower in high-risk thymomas/carcinomas than in low-risk thymomas • IHU and IC were lower in advanced-stage thymomas than in early-stage thymomas • Dual-energy CT helps differentiate among thymic epithelial tumours.
- Subjects :
- Adult
Aged
Carcinoma pathology
Contrast Media
Female
Humans
Image Processing, Computer-Assisted
Iopamidol
Male
Middle Aged
Multidetector Computed Tomography
Neoplasms, Glandular and Epithelial pathology
Prospective Studies
Thymoma pathology
Thymus Neoplasms pathology
Tomography, X-Ray Computed methods
Tumor Burden
Carcinoma diagnostic imaging
Neoplasms, Glandular and Epithelial diagnostic imaging
Thymoma diagnostic imaging
Thymus Neoplasms diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1432-1084
- Volume :
- 27
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- European radiology
- Publication Type :
- Academic Journal
- Accession number :
- 27553938
- Full Text :
- https://doi.org/10.1007/s00330-016-4542-9