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Paired Studies Comparing Clinical Profiles of Lewy Body Dementia with Alzheimer's and Parkinson's Diseases.

Authors :
Scharre DW
Chang SI
Nagaraja HN
Park A
Adeli A
Agrawal P
Kloos A
Kegelmeyer D
Linder S
Fritz N
Kostyk SK
Kataki M
Source :
Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2016 Oct 04; Vol. 54 (3), pp. 995-1004.
Publication Year :
2016

Abstract

Limited data compares clinical profiles of Lewy Body Dementia (LBD) with Alzheimer's disease (AD) and Parkinson's disease (PD). Twenty-one mildly demented ambulatory LBD subjects were individually matched by MMSE score with 21 AD subjects and by UPDRS motor score with 21 PD subjects. Matched by age, gender, education, and race, pairs were compared using cognitive, functional, behavioral, and motor measures. LBD group performed worse than PD on axial motor, gait, and balance measures. AD had more amnesia and orientation impairments, but less executive and visuospatial deficits than LBD subjects. LBD group had more sleepiness, cognitive/behavioral fluctuations, hallucinations, and sleep apnea than AD or PD. Axial motor, gait, and balance disturbances correlated with executive, visuospatial, and global cognition deficits. LBD is differentiated from AD and PD by retrieval memory, visuospatial, and executive deficits; axial motor, gait and balance impairments; sleepiness, cognitive/behavioral fluctuations, hallucinations, and sleep apnea.

Details

Language :
English
ISSN :
1875-8908
Volume :
54
Issue :
3
Database :
MEDLINE
Journal :
Journal of Alzheimer's disease : JAD
Publication Type :
Academic Journal
Accession number :
27567844
Full Text :
https://doi.org/10.3233/JAD-160384