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Ficus religiosa L. bark extracts inhibit infection by herpes simplex virus type 2 in vitro.
- Source :
-
Archives of virology [Arch Virol] 2016 Dec; Vol. 161 (12), pp. 3509-3514. Date of Electronic Publication: 2016 Aug 31. - Publication Year :
- 2016
-
Abstract
- Ficus religiosa extracts have been used in traditional Indian medicine to treat sexually transmitted infections such as gonorrhea and genital ulcers. The aim of this study was to investigate the antiviral activity of F. religiosa extracts against herpes simplex virus type 2 (HSV-2), the main causative agent of genital ulcers and sores. Water and chloroform bark extracts were the most active against HSV-2, and also against an acyclovir-resistant strain. We demonstrate that the water extract has a direct virus-inactivating activity. By contrast, the chloroform extract inhibits viral attachment and entry and limits the production of viral progeny.
- Subjects :
- Antiviral Agents isolation & purification
Herpesvirus 2, Human physiology
Humans
Plant Extracts isolation & purification
Virus Attachment drug effects
Virus Inactivation
Virus Internalization drug effects
Antiviral Agents pharmacology
Ficus chemistry
Herpesvirus 2, Human drug effects
Plant Bark chemistry
Plant Extracts pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1432-8798
- Volume :
- 161
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Archives of virology
- Publication Type :
- Academic Journal
- Accession number :
- 27581805
- Full Text :
- https://doi.org/10.1007/s00705-016-3032-3