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Long noncoding RNA #32 contributes to antiviral responses by controlling interferon-stimulated gene expression.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2016 Sep 13; Vol. 113 (37), pp. 10388-93. Date of Electronic Publication: 2016 Aug 31. - Publication Year :
- 2016
-
Abstract
- Despite the breadth of knowledge that exists regarding the function of long noncoding RNAs (lncRNAs) in biological phenomena, the role of lncRNAs in host antiviral responses is poorly understood. Here, we report that lncRNA#32 is associated with type I IFN signaling. The silencing of lncRNA#32 dramatically reduced the level of IFN-stimulated gene (ISG) expression, resulting in sensitivity to encephalomyocarditis virus (EMCV) infection. In contrast, the ectopic expression of lncRNA#32 significantly suppressed EMCV replication, suggesting that lncRNA#32 positively regulates the host antiviral response. We further demonstrated the suppressive function of lncRNA#32 in hepatitis B virus and hepatitis C virus infection. lncRNA#32 bound to activating transcription factor 2 (ATF2) and regulated ISG expression. Our results reveal a role for lncRNA#32 in host antiviral responses.<br />Competing Interests: The authors declare no conflict of interest.
- Subjects :
- Activating Transcription Factor 2 metabolism
Cardiovirus Infections genetics
Cardiovirus Infections virology
Cell Line, Tumor
Encephalomyocarditis virus genetics
Encephalomyocarditis virus pathogenicity
Gene Expression Regulation
Gene Silencing
Hepacivirus genetics
Hepacivirus pathogenicity
Hepatitis C genetics
Hepatitis C virology
Hepatocytes metabolism
Hepatocytes virology
Humans
Interferon Type I metabolism
RNA, Long Noncoding metabolism
Signal Transduction genetics
Virus Replication genetics
Activating Transcription Factor 2 genetics
Host-Pathogen Interactions genetics
Interferon Type I genetics
RNA, Long Noncoding genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1091-6490
- Volume :
- 113
- Issue :
- 37
- Database :
- MEDLINE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 27582466
- Full Text :
- https://doi.org/10.1073/pnas.1525022113