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A cognitive brain-computer interface for patients with amyotrophic lateral sclerosis.
- Source :
-
Progress in brain research [Prog Brain Res] 2016; Vol. 228, pp. 221-39. Date of Electronic Publication: 2016 Jun 10. - Publication Year :
- 2016
-
Abstract
- Brain-computer interfaces (BCIs) are often based on the control of sensorimotor processes, yet sensorimotor processes are impaired in patients suffering from amyotrophic lateral sclerosis (ALS). We devised a new paradigm that targets higher-level cognitive processes to transmit information from the user to the BCI. We instructed five ALS patients and twelve healthy subjects to either activate self-referential memories or to focus on a process without mnemonic content while recording a high-density electroencephalogram (EEG). Both tasks are designed to modulate activity in the default mode network (DMN) without involving sensorimotor pathways. We find that the two tasks can be distinguished after only one experimental session from the average of the combined bandpower modulations in the theta- (4-7Hz) and alpha-range (8-13Hz), with an average accuracy of 62.5% and 60.8% for healthy subjects and ALS patients, respectively. The spatial weights of the decoding algorithm show a preference for the parietal area, consistent with modulation of neural activity in primary nodes of the DMN.<br /> (© 2016 Elsevier B.V. All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Algorithms
Alpha Rhythm physiology
Brain Mapping
Electroencephalography
Electromyography
Female
Follow-Up Studies
Humans
Male
Middle Aged
Neurofeedback instrumentation
Principal Component Analysis
Theta Rhythm physiology
User-Computer Interface
Young Adult
Amyotrophic Lateral Sclerosis rehabilitation
Brain-Computer Interfaces
Cognition physiology
Neurofeedback methods
Parietal Lobe physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1875-7855
- Volume :
- 228
- Database :
- MEDLINE
- Journal :
- Progress in brain research
- Publication Type :
- Academic Journal
- Accession number :
- 27590971
- Full Text :
- https://doi.org/10.1016/bs.pbr.2016.04.022